Frontiers in pharmacology
Mechanism of BaP- regulated hepatic lipid metabolism via AhR activation and AR modulation
By Wang H, Zhang M, Wang X and 11 others.
Abstract
Objective
Benzo[a]pyrene (BaP) is a ubiquitous environmental pollutant that disturbs hepatic lipid metabolism. The androgen receptor (AR) protects hepatic lipid homeostasis, but whether BaP interferes with AR nuclear translocation through aryl hydrocarbon receptor (AhR) activation to cause metabolic disorders remains unknown in vivo and in vitro. This study aimed to clarify BaP-mediated regulation of AR signaling and its dependence on the AhR pathway during hepatic lipid metabolism.
