Drug design, development and therapy
Novel Hybrid Scaffold of Pyrazole, Thiazole, and [1,2,3]triazole: Eco-Friendly Synthesis by DABCO, Anti-HIV-1 RT, and In Silico Studies
By Al-Saleem MSM, Elhenawy AA, Al Sharif OF and 3 others.
Abstract
Background
The emergence of drug-resistant HIV-1 strains and limitations of current reverse transcriptase (RT) inhibitors support the development of structurally novel antiviral scaffolds. Hybrid azole systems may provide complementary interactions within the HIV-1 RT binding pocket.Purpose: To synthesize novel pyrazole-thiazole-[1,2,3]triazole hybrids using an eco-friendly DABCO-mediated approach and evaluate their anti-HIV-1 RT activity and structure-activity relationships using experimental and computational methods.
