Frontiers in immunology
Enrichment of the TRIM21-IgG complex in placental villi during HIV-1 infection
By Campo BN, de Sousa ESA, Pereira NZ and 9 others.
Abstract
Introduction
Innate immunity constitutes a pivotal defense mechanism protecting the maternal-fetal interface against viral pathogens. However, the dynamics of placental immunity in pregnant women with chronic HIV-1 infection undergoing suppressive antiretroviral therapy (ART) remain poorly understood. Tripartite motif (TRIM) family proteins act as critical host restriction factors or indirect regulators of antiviral pathways through ubiquitination cascades.