Biochemistry and biophysics reports
Scoparone protects against acetaminophen-induced acute liver injury: Insights from In vivo experiments and RNA sequencing
By Lv J, Liu L, Xia M and 2 others.
Abstract
Background
Scoparone (Sco) is known for its therapeutic effects in alleviating liver injury. This study aims to investigate the protective effects of Sco against acetaminophen-induced acute liver injury (ALI) and explore its underlying mechanisms through in vivo experiments and RNA sequencing.
Methods
Male Wistar rats were administered acetaminophen (400 mg/kg) to induce ALI, and Sco was given as an intervention. Liver injury and Sco's therapeutic efficacy were evaluated using histopathological analysis and biochemical indicators. RNA sequencing of liver tissue was performed to explore the molecular mechanisms, and differentially expressed genes were validated by qRT-PCR and in silico analysis.
