Frontiers in pharmacology
Microplastic exposure is associated with enhanced PI3K-Akt signaling in DSS-induced colitis: integrated bioinformatics analyses and in vivo validation
By Lu L, Yang Y, He S and 2 others.
Abstract
Background
Microplastics (MPs) are widely distributed in the environment and may aggravate ulcerative colitis (UC), but the underlying molecular mechanisms remain unclear.
Methods
We integrated network toxicology, RNA-seq-based differential expression analysis, molecular docking, GeneMANIA-based functional association analysis, and experimental validation in a murine DSS-induced colitis model.
