Frontiers in public health
Prevalence and transmission of pretreatment drug resistance and acquired drug resistance among people living with HIV-1 in Chongqing, China, 2014-2024
By Gao W, Li J, Li M and 3 others.
Abstract
Objectives
To explore the epidemic trends of pretreatment drug resistance (PDR) and acquired drug resistance (ADR) among people living with HIV (PLWH) from 2014 to 2024 in Chongqing, China.
Methods
Samples and clinical data of PLWH were collected from 2014 to 2024. The HIV-1 pol gene was amplified using One-step reverse transcription-polymerase chain reaction (RT-PCR) and nested PCR. HIV-1 drug resistance and subtype were analyzed by the HIV drug resistance database of Stanford University. Logistic regression analysis was identified the risk factor associated with HIV drug resistance (HIVDR).