Effects of calcium-containing solutions on fluorescence-detectable plaque area and enamel mineral volume: an in vitro and exploratory clinical study

Background

Calcium-containing biomimetic materials have been investigated as adjunctive approaches for managing early enamel demineralization; however, clinical evidence regarding calcium-containing oral sprays remains limited. This study evaluated the effects of calcium-based solutions on fluorescence-detectable plaque-associated area on tooth surfaces through an in vitro experiment and an exploratory randomized clinical trial.