Brain and behavior
Glymphatic System Dysfunction and its Associated Factors in Wilson's Disease: A DTI-ALPS Study
By Zhu L, Wu T, Zhang LJ and 12 others.
Abstract
Background
Wilson's disease (WD) is a genetic disorder of copper (Cu) metabolism that causes Cu accumulation in multiple organs, particularly the liver and brain, resulting in progressive multisystem damage. This study investigated glymphatic system function and its associated factors in patients with WD.
Methods
Seventy-one patients with WD (19 hepatic, 52 neurological) and 15 healthy controls (HCs) were enrolled. The analysis along the perivascular space (ALPS) index was quantified using diffusion tensor imaging (DTI-ALPS). Comparisons were performed between patients and than HCs, and across WD phenotypes, and correlations with clinical characteristics were analyzed.
