International journal of general medicine
Prognostic Significance of the CALLY Index in Heart Failure
By Özkoç M, Aydemir S, Özmen M and 1 others.
Abstract
Background
Heart failure (HF) is a global health problem with high mortality rates. Systemic inflammation and neurohumoral dysfunction play an important role in its pathophysiology. Unlike other subtypes, HF with preserved ejection fraction (HFpEF) represents a highly heterogeneous group of patients. Therefore, the phenotyping must be conducted with great care.
Objective
In our study, we aimed to evaluate the relationship between the C-reactive protein-albumin-lymphocyte (CALLY)-index, a composite biomarker reflecting the nutritional, inflammation and immune status of the patient, and long-term mortality due to all causes in HF. Subjects and methods: Our retrospective, single-centre study included patients diagnosed with HF and followed up at our clinic between 2018-2025. The CALLY-index was calculated using the patients' blood tests at the time of hospital admission. In this study, where the primary endpoint was all-cause mortality, patients were divided into two groups according to their survival status. Variables independently associated with mortality were identified using Cox-regression analysis. To assess the predictive power of the CALLY-index for mortality, a Receiver Operating Characteristic (ROC) analysis was performed and the area under the curve (AUC) was calculated.