Effect of Herbal Extracts on Antituberculosis Drug-Induced Hepatotoxicity: A Systematic Review

Background

Tuberculosis (TB) remains a major global health challenge. While effective, first-line antitubercular drugs such as isoniazid and rifampicin often cause hepatotoxicity, limiting treatment safety. Herbal extracts with antioxidant and hepatoprotective properties may help mitigate this liver damage. This systematic review evaluates the protective effects of plant extracts against antitubercular drug-induced hepatotoxicity, aiming to inform potential adjuvant strategies.