Frontiers in oncology
Margin status, re-excision, and completion mastectomy after oncoplastic versus conventional breast-conserving surgery for breast cancer: a systematic review and meta-analysis
By Hou N, Ye L, Huang W and 2 others.
Abstract
Background
Oncoplastic breast-conserving surgery (OBCS) may permit wider excision within a breast-conserving approach, but its effects on margin control and subsequent surgery remain uncertain.
Methods
We searched PubMed/MEDLINE, Embase, Web of Science Core Collection, Scopus, and the Cochrane Library from inception through 25 June 2026 for comparative studies of OBCS versus conventional breast-conserving surgery (BCS). Primary outcomes were initial positive margin, re-excision, completion/conversion mastectomy, and any margin-related reoperation. Secondary outcomes were negative/clear margin, recurrence, and complications. Risk ratios (RRs) with 95% confidence intervals (CIs) were pooled using random-effects Mantel-Haenszel models. Methodological quality was assessed using the Newcastle-Ottawa Scale. The protocol was registered in PROSPERO (CRD420261439265).
