International journal of nanomedicine
Engineered Human Ferritin Nanocage Enhances Intracellular Vancomycin Delivery and Activity Against Gram-Positive Bacteria in Macrophages
By Cao B, Wang M, Li T and 4 others.
Abstract
Purpose
The limited cellular penetration of vancomycin (Van) restricts its intracellular availability and represents a major challenge for treating infections caused by intracellular Gram-positive bacteria. We investigated whether the engineered ferritin nanocage HFn-D93G could improve intracellular Van delivery while preserving the intrinsic antibacterial activity of Van.