Diabetes, metabolic syndrome and obesity : targets and therapy
Age-Specific Associations Between the Testosterone-to-Estradiol Ratio and Metabolic Syndrome Components in Middle-Aged and Elderly Chinese Men
By Ma G, Chen X, Miao Y and 2 others.
Abstract
Background
Metabolic syndrome (MetS) is common in aging men, but the age-specific relationship between the testosterone-to-estradiol (T/E2) ratio and metabolic abnormalities remains insufficiently characterized. This study evaluated age-stratified associations between the T/E2 ratio and MetS-related parameters in middle-aged and elderly Chinese men.
Methods
This retrospective cross-sectional study included 120 Chinese men aged 46-75 years. Participants were divided into three age groups: 46-55, 56-65, and 66-75 years. Serum testosterone, estradiol, sex hormone-binding globulin (SHBG), anthropometric indices, blood pressure, fasting blood glucose, and lipid profiles were assessed. MetS components were defined according to IDF-based criteria, and TyG index and TyG-BMI were calculated. Age-stratified Pearson correlation analyses were performed, with Spearman correlation and FDR adjustment used for sensitivity analyses.
