Diabetes, metabolic syndrome and obesity : targets and therapy
Evaluate the Risk Factors of Mild Cognitive Impairment (MCI) in Patients with Type 2 Diabetes Mellitus (T2DM): A Cross-Sectional Study
By Cao Y, Lei C, Liu J and 9 others.
Abstract
Objective
To explore the potential incremental value of metabolic-inflammatory and insulin-resistance indices for diagnosing mild cognitive impairment (MCI) in type 2 diabetes (T2DM), and to furnish new candidate tools and insights for the risk stratification and early recognition of diabetes-related cognitive dysfunction.
Methods
This cross-sectional, observational study was jointly conducted by two tertiary endocrine centers in northwestern China. A uniform assessment of cognitive status was performed using the Chinese versions of the Montreal Cognitive Assessment (MoCA). MCI was defined as MoCA < 26. Baseline clinical characteristics, metabolic-inflammatory parameters and insulin-resistance indices were systematically compared between groups. Candidate predictors were first compressed via Lasso regression; key retained variables were then used to develop a binary logistic prediction model. The model's discrimination was assessed via ROC curves, and its calibration was evaluated by the Hosmer‑Lemeshow test combined with calibration plots. Decision-curve analysis (DCA) and clinical impact curves (CIC) were further employed to quantify net benefit and reclassification across a range of risk thresholds, providing a comprehensive appraisal of the model's clinical utility.
