Journal of pain research
Association of Serum CX3CL1 and TSLP Expression with Postoperative Pain Severity in Patients Undergoing Laparoscopic Cholecystectomy: A Prospective Study
By Li C, Yang X, Shi W and 5 others.
Abstract
Objective
To investigate the association between preoperative serum CX3CL1 and TSLP levels and postoperative pain severity in patients with acute calculous cholecystitis undergoing laparoscopic cholecystectomy (LC).
Methods
We prospectively enrolled 379 patients with acute calculous cholecystitis undergoing LC. According to the 24-hour postoperative visual analog scale (VAS) score, patients were classified into mild pain (MP, n=261) and moderate-to-severe pain (MSP, n=118) groups. Preoperative serum CX3CL1 and TSLP were measured by enzyme-linked immunosorbent assay (ELISA). Receiver operating characteristic (ROC) curves were constructed to evaluate their predictive value, alone and in combination. Multivariable logistic regression identified independent risk factors. A nomogram was developed and internally validated using a 7:3 split.
