Predictive Value of Perioperative Systemic Inflammation Response Index Dynamics for Postoperative Pulmonary Infection Following Esophagectomy: A Multicenter Retrospective Cohort Study

Background

Postoperative Pulmonary Infection (POPI) is a leading cause of morbidity and mortality following esophagectomy. Current static inflammatory markers lack the specificity to distinguish between surgical stress and early infection. This study aims to investigate whether the dynamic perioperative changes in the Systemic Inflammation Response Index (SIRI) can reflect the host's "inflammation-immune" balance and predict the occurrence of POPI.