BMC pharmacology & toxicology
Association of elevated linezolid trough concentrations with hyperlactatemia in elderly patients: a multicenter observational study in China
By Yuan Y, Liu T, Wu X and 13 others.
Abstract
Background
The association between hyperlactatemia (HLA) and linezolid concentrations in elderly patients remains poorly understood. This study aimed to explore the associations among linezolid trough concentrations, HLA, and clinical outcomes in elderly patients.
Methods
Elderly patients receiving linezolid treatment at four tertiary hospitals in Beijing between May 2021 and June 2023 were enrolled. Linezolid concentrations and arterial lactate levels were dynamically monitored, and risk factors for HLA and mortality were analyzed to develop a clinical prediction model.