Tobacco induced diseases
Association between urinary NNAL concentrations and osteoarthritis: Evidence from NHANES 2007-2012
By Liu J, Zhang J, Guo Z and 3 others.
Abstract
Introduction
Osteoarthritis (OA) is the most prevalent degenerative joint disorder globally, yet the impact of smoking on its development remains contentious. The compound 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a principal metabolite of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), is a well-recognized biomarker for smoking exposure. This study aimed to use urinary NNAL as a biomarker to evaluate the association between tobacco exposure and OA.
