Effects of trazodone on polysomnographic sleep architecture in patients with depression and sleep disorders: a systematic review and exploratory meta-analysis

Objective

Sleep disturbance and cognitive impairment are common in depression. Trazodone is often used for sleep problems and may improve cognition by modifying sleep architecture. However, its effects on specific polysomnography-derived sleep stages remain unclear. This systematic review and exploratory meta-analysis aimed to investigate trazodone's effects on sleep architecture in patients with depression and sleep disorders.