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Alzheimer's & dementia
By Li J, Wang Y, Yin C and 8 others.
The contribution of extracerebral microvascular disease (MVD) burden to dementia risk remains unclear.
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Among 484,896 UK Biobank participants (median follow-up 8.5 years), baseline extracerebral MVD (retinopathy, nephropathy, peripheral neuropathy) and incident dementia were identified via hospital records. Aging-related brain changes were evaluated using magnetic resonance imaging (MRI) -derived volumes and white matter integrity.
MVD was 2.6 times more prevalent among participants who developed dementia than dementia-free individuals (8.0% vs 3.1%) and ranked second among vascular comorbidities after coronary artery disease. Each additional MVD burden was associated with a higher dementia risk, comparable to coronary artery disease (hazard ratio = 1.69 vs. 1.72). Earlier onset conferred stronger risk, and coexisting vascular diseases further amplified associations (p-trend < 0.001). MVD burden was also associated with global brain atrophy and reduced white matter integrity.
Extracerebral MVD burden is associated with dementia risks and brain imaging changes, supporting integrated vascular risk stratification and management for dementia.
Published in Alzheimer's & dementia (Amsterdam, Netherlands). The abstract is shown as published and remains the work of its authors; read the full article at the source.
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