Frontiers in pharmacology
Pediatric bronchial ulcers induced by ibuprofen overdose: a case report combined with network toxicology to decipher potential mechanisms
By Huang Y, Qiu G, Li Q and 2 others.
Abstract
Background
Ibuprofen overdose is commonly associated with gastrointestinal and renal toxicity; however, severe respiratory complications such as bronchial ulceration are rarely reported, and the underlying molecular mechanisms are poorly understood.
Objective
To investigate the potential molecular mechanisms of bronchial ulceration induced by an extreme ibuprofen overdose in a pediatric patient by integrating clinical observation with network toxicology-based computational predictions.
