Small-Bowel Perforation Caused by Multiple…

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A man in his 70s with a heavy smoking history was incidentally found, during an admission for bowel obstruction, to have left-lung lesions with hilar and subcarinal lymphadenopathy on CT, without abdominal disease. Bronchoscopic biopsy showed adenocarcinoma with a programmed death ligand 1 (PD-L1) tumor proportion score of 100% and no actionable driver alteration. Based on an ipsilateral separate-lobe pulmonary nodule, mediastinal nodal involvement, and a clinically suspected sacral bone metastasis, the disease was staged as cT4N2M1b, stage IVA. First-line pembrolizumab monotherapy was administered, and the thoracic disease remained controlled, with regression of the primary lesion and lymph nodes. After a cutaneous immune-related adverse event treated with corticosteroids (with pembrolizumab discontinuation), he developed melena and severe iron-deficiency anemia requiring transfusion. Esophagogastroduodenoscopy and colonoscopy identified no bleeding source, and obscure (suspected small-bowel) gastrointestinal bleeding was diagnosed. Approximately 2 months later, after an episode of shock, possibly related to infection and adrenal insufficiency following corticosteroid withdrawal, he developed acute abdominal pain with free intraperitoneal air. Emergency surgery revealed multiple small-bowel tumors with a perforation; partial small-bowel resection with functional end-to-end anastomosis and peritoneal lavage was performed. Histopathology showed multiple metastatic adenocarcinomas of the small intestine, a perforated metastatic ulcer, and mesenteric lymph node metastasis. Immunohistochemistry showed cytokeratin (CK) 7 positivity and CK20, caudal-type homeobox 2 (CDX2), thyroid transcription factor-1 (TTF-1), novel aspartic proteinase of the pepsin family A (Napsin A), CK5/6, and p40 negativity, matching the immunophenotype of the original lung biopsy. These findings were inconsistent with an intestinal primary and consistent with metastatic lung adenocarcinoma. Postoperative paralytic ileus resolved, and the patient was discharged on best supportive care.

Small-Bowel Perforation Caused by Multiple Metastases from Lung Adenocarcinoma Preceded by Obscure Gastrointestinal Bleeding: A Case Report

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