Frontiers in molecular neuroscience
Guanfacine and HCN channels: bridging neuroinflammation and prefrontal cortex function in autism spectrum disorder
By Yamamuro K, Yamauchi T and Makinodan M.
Abstract
Background
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social communication differences and restricted, repetitive behaviors. Convergent evidence implicates prefrontal cortex (PFC) circuit dysregulation and chronic neuroimmune activation in ASD. Despite increasing off-label use of guanfacine in children and adolescents with autism, its molecular and immunological rationale remains incompletely synthesized.
