Identification of Plasma Protein Biomarkers for Early-Onset Stroke through Mendelian Randomization

Background

Stroke incidence is declining in older adults but rising in younger populations. Circulating plasma proteins are promising biomarkers of vascular disease, yet their causal role in early-onset stroke (EOS) remains unclear. We used proteome-wide Mendelian randomization (MR) to identify proteins causally associated with EOS and its subtypes.