Revista de la Sociedad Argentina de Diabetes
Progresión a diabetes, remisión a normalidad y epidemiología
By Guillermo Marcucci.
Abstract
Background
Prediabetes is a highly prevalent and heterogeneous condition. Its phenotypic characterization is crucial, as metabolic profiles determine both the individual risk of progression to type 2 diabetes mellitus (T2DM) and the potential for regression toward normal glucose tolerance (NGT). Variations in prevalence and metabolic trajectories depend on the diagnostic criteria used and geographic distribution.
Objectives
To analyze the epidemiological, phenotypic, and pathophysiological factors influencing prediabetes metabolic trajectories, evaluating the risk of progression to T2DM and the probability of regression to normoglycemia. Materials and Methods: review and analysis of global, multiethnic epidemiological data, including subgroup behavior by sex and age, along with a syndromic analysis of 103 prospective cohort studies worldwide in individuals with intermediate hyperglycemia (IH). Variables such as impaired fasting glucose (IFG), impaired glucose tolerance (IGT), HbA1c, and 1-hour plasma glucose (1-h PG) were evaluated and correlated with reference standards like the hyperinsulinemic-euglycemic clamp.
