Multivariate Analysis on Insulin Resistance and Blood Pressure in Indonesian Office Workers: Cross-Sectional Observational Study

Insulin resistance and hypertension are closely linked conditions that share common pathophysiological mechanisms. Increased insulin resistance among sedentary office workers heightens the risk of developing hypertension and cardiovascular disease. This study aimed to assess the profile of insulin resistance and its relationship with blood pressure among office workers in Indonesia. After obtaining informed consent, participants provided information on smoking habits and physical activity. Blood pressure measurements and venous blood samples were collected to determine fasting blood glucose and fasting insulin levels. Data were analyzed using the Spearman correlation test and multivariate logistic regression. A total of 102 participants were enrolled, with a mean age of 40.21 ± 1.12 years. Most participants were classified as obese grade I, with normal insulin resistance and normal blood pressure profiles. A weak but significant correlation was found between insulin resistance and systolic blood pressure (r = 0.387; p < 0.001) and diastolic blood pressure (r = 0.296; p = 0.005). In the multivariate logistic regression analysis, none of the factors were statistically significant independent predictors of hypertension (p > 0.05). Overall, insulin resistance was weakly but significantly correlated with increased blood pressure; however, no individual factor was independently associated with hypertension.