Состояние антибиотикорезистентности у бактерий, вызывающих осложненные инфекции мочевыводящих путей у беременных женщин с мочекаменной болезнью

Relevance: Antimicrobial resistance among uropathogens in complicated urinary tract infections (UTIs) in pregnant women, especially when combined with urolithiasis, complicates the administration of empirical therapy and jeopardizes the safety of both the mother and the fetus, underscoring the need to update local microbiological data. This study aimed to assess the nature and prevalence of antibiotic resistance among uropathogens causing complicated urinary tract infections associated with urolithiasis in pregnant women. Materials and Methods: This retrospective descriptive analysis was conducted from June to September 2023 at a tertiary-level urology center in Kyrgyzstan. The study included 110 medical records of pregnant patients with clinically confirmed complicated pyelonephritis associated with urolithiasis. Urine cultures were performed on CLED agar, as well as on Endo and CHROMagar Orientation media. Microorganisms were identified using the VITEK 2 Compact system and biochemical tests. Antimicrobial susceptibility testing was performed using the Kirby-Bauer disk diffusion method. ESBL production, multidrug resistance, and resistance to selected antimicrobial groups were analyzed using descriptive statistics and comparative tests in SPSS 25.0.