Cureus
Laparoscopic and Robot-Assisted Surgery for Gestational Trophoblastic Disease: A Scoping Review of Patient Selection and Intraoperative Precautions
By Rei Gou, 真紀子 湯田 and Hiroko Fukasawa.
Abstract
Guidelines for gestational trophoblastic disease (GTD) state when hysterectomy is indicated, but say little about the operative route or what should be recorded during the operation.We conducted a Joanna Briggs Institute (JBI) scoping review, reported to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR), of laparoscopic and robot-assisted operations that resected or biopsied GTD tissue to establish which patients undergo these operations and what intraoperative precautions the reports contain.PubMed (August 18, 2026; 449 records) and Ichushi-Web (August 20, 2026; 329 records) were searched without language or date restriction, and backward citation chasing added two reports.The review maps what is reported; it estimates neither safety nor effectiveness, and no meta-analysis was performed.In total, 64 original reports describing 67 operations entered the main analysis, alongside 24 Ichushi-Web conference records as a supplementary layer; 54 were case reports, and the literature spans 1995 to 2026.GTD had been diagnosed before 38 of the 67 operations; before the other 29, it had not.The details needed to study intraperitoneal containment were rarely described: use or nonuse of a uterine manipulator in five of 36 evaluable reports of operations on a retained uterus, morcellation in three of 36, a retrieval bag in two of 50, peritoneal washing cytology in six of 53, and pneumoperitoneum pressure in none of 52.A mechanical containment token was present in 17 of 57 evaluable reports, but of the 16 that could also be assessed for wording, 12 never used the words spillage, seeding, dissemination, or port-site.Port-site events were charted as an outcome and were not reported in 43 of the 49 reports in which that field was evaluable.Laparoscopic and robot-assisted surgery for GTD has been reported since 1995, mainly as single cases and in a preoperatively mixed population, and the intraoperative detail that would allow containment to be studied is usually absent.The gap this review identifies is one of reporting rather than of technique.










