Hepatoprotective Effects of Dulaglutide against Methotrexate-Induced Liver Injury in Rats

Background and Objectives: The cellular antioxidant defense system is disrupted, which results in hepatotoxicity. When the antioxidant defence system is weakened, hepatocyte oxidative damage results from an increase in reactive oxygen radicals. The chemotherapeutic and immunosuppressive drug methotrexate (MTX) is often linked to hepatotoxicity, a serious side effect with uncertain consequences. Therefore, the current study looks into the potential preventive effect of dulaglutide (DUL) against liver damage caused by MTX.