Sex-Specific Associations of Helicobacter pylori Seropositivity and Intestinal Metaplasia with Colorectal Adenoma: A Korean Multicenter Cross-Sectional Study

Purpose

Male sex is a recognized risk factor for colorectal adenoma, yet whether the associations of Helicobacter pylori, atrophic gastritis (AG), and intestinal metaplasia (IM) with colorectal adenoma differ by sex remains unclear. This study evaluated the sexstratified and combined associations of anti-H. pylori IgG seropositivity, AG, and IM with conventional colorectal adenoma. Materials and Methods: This multicenter cross-sectional study included 806 participants from a Korean health-screening cohort who underwent gastroscopy with H. pylori testing and colonoscopy within 3 years. Anti-H. pylori IgG seropositivity was determined by enzyme-linked immunosorbent assay, AG and IM were assessed endoscopically. Multivariable logistic regression models were adjusted for age, sex, body mass index, smoking, and alcohol consumption.