Utilizing bidirectional Mendelian randomization to uncover the relationship between infectious diseases and primary biliary cholangitis

Aims

To explore the causal relationship between infectious disease pathogen antibodies and primary biliary cholangitis (PBC) using bidirectional Mendelian randomization (MR) and verify whether PBC has a reverse causal effect on the body’s antibody response to infectious pathogens, thereby providing new insights into PBC’s etiology and a theoretical basis for its prevention and treatment.