A Critical Review of Samprapti of Madhumeha in Sutrasthana 17 of Charaka Samhita and its Correlation with Type 2 Diabetes Mellitus Pathophysiology

Type 2 diabetes mellitus is a major global health burden, and Ayurveda had described a comparable condition, Madhumeha, more than two thousand years earlier. Charaka Samhita, Sutrasthana 17, Sloka 78-81, gives an unusually compact account of Madhumeha's pathogenesis that has drawn less scholarly attention than the fuller description in Nidanasthana.

Objectives

This review examines these four Sloka closely, compares them with the treatment of Prameha and Madhumeha in Sushruta Samhita, Ashtanga Hridaya, Madhava Nidana and Sharangadhara Samhita, and builds a stage-by-stage comparison between this classical pathological model and the current understanding of type 2 diabetes mellitus.