Alterations of the von Willebrand factor/a disintegrin and metalloproteinase with thrombospondin type 1 motif-13 axis in transfusion-dependent β-thalassemia: A cross-sectional study

Abstract: BACKGROUND: In transfusion-dependent (TD) β-thalassemia patients, iron overload causes prothrombotic hemostatic abnormalities, rendering them prone to thrombotic events. Von Willebrand factor (vWF) and a disintegrin and metalloproteinase with thrombospondin type 1 motif-13 (ADAMTS-13) are closely linked markers that can explain and predict thrombotic events.

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