The Effect of Packed Red Blood Cell Transfusion on Complete Blood Count and Hemoglobin Fractions in Adult Patients with Sickle Cell Disease: A Prospective Single-Center Cohort Study in Saudi Arabia

Background

Sickle cell disease (SCD) is a genetic disease where a mutation in beta-globin results in an increased hemoglobin S percentage (Hgb S%), which is responsible for the crisis. The aim of this study was to determine the impact of each unit packed red blood cell (PRBC) simple transfusion on complete blood count (CBC) and high-performance liquid chromatography (HPLC) parameters in adult patients with SCD.