Assessment of serological markers (interleukin-37, interleukin-40, antinuclear antibody and PA-Ab) and protein tyrosine phosphatase nonreceptor type 22 genetic profiles in children with immune thrombocytopenia: A case–control study

Abstract: BACKGROUND: Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by reduced platelet count; this condition ranges from mild symptoms to life-threatening bleeding. The protein tyrosine phosphatase nonreceptor type 22 ( PTPN22) gene codes for an enzyme called phosphatase, which controls cell signals in immune responses, specifically in T-cells. Mutations within this gene could impact the functioning of the immune system and have been considered risk factors in ITP patients.