Increasing Trends of Linezolid Resistant Enterococcus Species in a Tertiary Care Hospital, Islamabad

Objective

To conduct a five-year surveillance analysis of the epidemiological trends, demographic distribution and susceptibility patterns of linezolid-resistant Enterococcus (LRE), addressing a critical evidence gap in a region where no prior data are available. Methodology: A retrospective, cross-sectional study was conducted from January 2020 to December 2024 at the Microbiology Laboratory, Shifa International Hospital, Islamabad. All non-duplicate Enterococcus species isolated from different specimens were included in the study. Demographic, specimen and susceptibility data were retrieved from the laboratory information system (LIS). Enterococcus species that were not susceptible to linezolid (including both intermediate and resistant isolates) were included in LRE. Data analysis was performed using SPSS software version 25.