Population Pharmacokinetics of Amikacin and Monte Carlo Simulation Study in Critically Ill Septic Patients Undergoing Continuous Renal Replacement Therapy with CytoSorb® or oXiris®

Background

Adsorptive devices, including CytoSorb® and oXiris®, are increasingly added to continuous renal replacement therapy (CRRT) in septic patients, but their effect on amikacin clearance and exposure is unknown. We characterized amikacin pharmacokinetics (PK) during adsorptive CRRT and derived dosing implications.