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Pharmaceutics
By Xiaoyun Wang, Jianxia Huang, Qiong He and 1 others.
This study aimed to evaluate the efficacy of photodynamic therapy (PDT) compared to observation in managing low-grade squamous intraepithelial lesions (LSILs) with high-risk HPV infection.
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We conducted a retrospective cohort study involving 608 patients with pathologically confirmed LSILs and Hr-HPV infection, divided into PDT or observation groups based on clinical preference and evaluation. PDT was administered as a routine clinical treatment option at our center. Follow-up at 6 months included HPV testing, cytology, and colposcopy.
The PDT group exhibited significantly higher regression rates (92.5% vs. 48.3%) and complete HPV clearance rates (80.8% vs. 37.3%) than the observation group. Adverse effects from PDT were mild and transient, with no cervical scarring or skin photosensitivity observed. Ten patients conceived successfully post-PDT, with five uncomplicated deliveries to date.
These findings suggest that PDT is an effective, non-invasive treatment for LSILs with Hr-HPV infection, demonstrating favorable regression and safety profiles while preserving cervical integrity, particularly in reproductive-aged women.
Published in Pharmaceutics. The abstract is shown as published and remains the work of its authors; read the full article at the source.
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