Pharmaceutics
LC–MS/MS Quantification of the Anti-Tuberculosis Macrolide Arenicolide A in Rat Plasma: Method Validation and Pharmacokinetic Application
By Dahan Kim, Dahan Kim, Eun Kyung Shin and 12 others.
Abstract
Background/Objectives: Arenicolide A (ArA), a 26-membered macrolide from Micromonospora sp. GR10, is active against Mycobacterium tuberculosis, including multidrug-resistant strains. We developed and validated a liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for ArA in rat plasma and applied it to pharmacokinetic studies.