Indirect Skin Homeostasis Modulation by an Essential Oil Blend in Mice with Insomnia Comorbid Anxiety: Sensitivity of Dermal Fibroblasts to Exogenously Applied Circulating Molecules

Background/Objectives: Studies have confirmed that essential oils extracted from aromatic plants exert mood-regulating and skin-beneficial effects. Although the concept of “emotional skincare” has attracted growing research interest, experimental evidence supporting the indirect skin-protective effects of essential oils through emotional regulation remains limited. This study investigates the indirect effect of an essential oil blend (EOB) on skin homeostasis in mice with insomnia comorbid anxiety (ICA, a pharmacologically validated emotional stress model induced by para-chlorophenylalanine) and aims to profile the sensitivity of dermal fibroblasts to candidate circulating molecules identified from EOB-treated ICA mice, thereby laying a mechanistic foundation for emotional skincare research.