Pharmaceuticals
Incensole Acetate Regulates the Sirtuin–Insulin Signaling Axis in an Experimental Alzheimer’s Disease Model
By Rabia Kalkan Cakmak, Bahar Sarikamis Johnson, Nilüfer Ercin and 3 others.
Abstract
Background/Objectives: Alzheimer’s disease (AD) is associated with impaired brain insulin signaling, oxidative stress, and neuroinflammation. This study investigated the effects of incensole acetate (IA) on sirtuin-associated insulin-signaling and cellular stress-response pathways using integrated computational and in vitro approaches.