Nutrients
Nutritional Status and Cognition in Older Adults: Modification by Apolipoprotein E ε4
By Young Min Choe, Jihyun Kim, Jihyun Kim and 9 others.
Abstract
Background
Malnutrition is a modifiable risk factor for late-life cognitive decline, but whether its cognitive correlates vary by genetic risk is unclear. We examined whether the apolipoprotein E ε4 allele (APOE4) modifies associations of the Mini-Nutritional Assessment (MNA) and its subscales with global cognition.
Methods
In this cross-sectional analysis of 196 non-demented older Korean adults from the General Lifestyle and Alzheimer’s Disease (GLAD) cohort, multiple linear regression tested associations of MNA total (MNA-T), screening (MNA-S), and assessment (MNA-A) scores with the CERAD total score (TS), including MNA × APOE4 interactions. Exploratory analyses examined one representative item per a priori nutritional domain.