Nutrients
The Effects of Combined Caffeine and Sodium Bicarbonate Supplementation on Exercise Performance, Physiological Responses, and Gastrointestinal Tolerability: A Systematic Review and Meta-Analysis
By Xiang Chen, Wenhui Tu and Jun Wang.
Abstract
Background
Caffeine and sodium bicarbonate can individually enhance exercise performance, but whether their combined use provides additional benefits and how it affects physiological responses and gastrointestinal (GI) tolerability remain unclear.
Objective
This systematic review and meta-analysis aimed to evaluate the effects of combined caffeine and sodium bicarbonate (CAF + SB) supplementation on exercise performance, physiological responses, and GI tolerability, and to determine whether it provides additional benefits compared with placebo or either supplement alone.
