Exploring Mechanisms and Therapeutic Strategies for Metformin Hydrochloride-Induced Diarrhea and Gastrointestinal Intolerance: A Bibliometric Analysis

Background

Metformin hydrochloride (MET) gastrointestinal adverse effects (GAEs) are associated with intestinal accumulation, gut microbiota alterations, transporter saturation, and increased serotonin and lactate levels. This study mapped the scientific literature indexed in Web of Science (WoS) and Scopus, with MET-induced gastrointestinal intolerance and diarrhea as the primary research focus, concentrating on mechanisms and strategies to mitigate GAEs.