Medical Sciences
Integrated Profiling of TNF Superfamily Ligands and Lung Inflammatory Markers in Tuberculosis-Type 2 Diabetes Mellitus Comorbidity
By Nandita Ganesh, Rajesh Kumar Radhakrishnan, Fathima Sumaira and 6 others.
Abstract
Background
Type 2 diabetes mellitus (T2DM) increases susceptibility to tuberculosis (TB) and contributes to immune dysregulation, exaggerated inflammation and poor clinical outcomes. Acute-phase proteins (APPs), lung-associated markers (LMs) and TNF superfamily ligands play a crucial role in inflammatory and immune signaling; however, an integrated approach in understanding the inflammatory profile and their immunological association in TB-T2DM remains underexplored.