Autologous Collagen-Induced Chondrogenesis (ACIC) for Osteochondral Lesions of the Talus: A Systematic Review and Meta-Analysis

Background and Objectives: Autologous Collagen-Induced Chondrogenesis (ACIC) is a regenerative technique for treating osteochondral lesions that combines microfracture with the application of an injectable atelocollagen scaffold over the defect. This scaffold stabilizes the marrow clot and promotes the retention of mesenchymal stem cells at the repair site. Its use for Osteochondral Lesions of the Talus (OLTs) has increased in recent years, with several studies reporting favorable clinical outcomes. However, the available evidence has not yet been comprehensively synthesized. The aim of this systematic review and meta-analysis was to evaluate the clinical outcomes of ACIC for the treatment of OLTs. Materials and Methods: This study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Studies evaluating ACIC for the treatment of OLTs were systematically identified and selected. Data regarding patient characteristics, surgical technique, and clinical outcomes were extracted and analyzed.