Multiscale Characterization of Mesh–Tissue Interface Disorganization in Chronic Mesh-Associated Inflammatory Remodeling Using Histology and Atomic Force Microscopy: An Exploratory Study

Background/Objectives: Chronic mesh-associated inflammatory remodeling may complicate abdominal wall repair through persistent foreign body response, fibrosis, and extracellular matrix disorganization. This exploratory study compared pathological and well-integrated mesh–tissue interfaces using histology and atomic force microscopy (AFM).

Methods