Journal of Molecular Pathology
Molecular Pathology Insights into ALS Susceptibility: Exploratory Association of CYP46A1 rs754203 in Brazilian Case–Control Study
By Ângela Adamski da Silva Reis, Caroline Christine Pincela da Costa, Diolina Gonçalves da Silva and 2 others.
Abstract
Background/Objectives: Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease, and alterations in cholesterol metabolism may contribute to motor neuron vulnerability. This study investigated CYP7B1 rs121908613 and CYP46A1 rs754203 in relation to ALS susceptibility in a Brazilian case–control study.