Journal of Clinical Medicine
Timing of First Systemic Antibiotic Administration and Risk of Deep Infection in Adults with Open Long-Bone Fractures: A Systematic Review and Threshold-Specific Evidence Synthesis
By Nguyen The Diep, Nguyen Minh Chau, Phan Thanh Nam and 1 others.
Abstract
Background/Objectives: Early systemic antibiotics are central to open-fracture care, but a 60 min operational target does not establish a biological infection threshold. We examined how time origin, cutoff, and outcome definition affect interpretation of reported associations.