Oral Antibiotic Preparation Is Associated with Lower Surgical Site Infection After Ileostomy Closure: A Retrospective Cohort Study

Background/Objectives: Surgical site infection (SSI) remains a common complication after ileostomy closure. Mechanical bowel preparation (MBP) and oral antibiotic preparation are often bundled together, so their independent contributions to SSI risk are unclear. We evaluated the adjusted associations of oral antibiotic preparation and MBP with SSI after ileostomy closure, a setting in which these two components have rarely been examined separately.